After 20 years abroad, Mark Renton returns to Scotland and reunites with his old friends Sick Boy, Spud and Begbie.

In Glasgow, Scotland, while a mysterious pandemic begins to spread around the world, Susan, a brilliant epidemiologist, falls in love with Michael, a skillful cook.

A myriad of outrageous calamities befalls an eccentric English clan with more than a few skeletons in its closets when the family's patriarch dies an unexpected death.